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CREMP might be present in multiple isoforms in the chicken genome (e.g. analogous to the multiplicity of keratin-associated proteins in vertebrates [3]).
Results depict that a singular periostin isoform dominated the rat muscle, contrasting to multiple isoforms in C2C12 myoblast cells.
In this review, we will first describe the plakins, desmoplakin, plectin, envoplakin and periplakin and then describe two other mammalian plakins, Bullous pemphigoid antigen 1 (BPand) and microtubule actin cross-linking factor 1 (MACF1), that are expressed in multiple isoforms in different tissues.
Acetyl-CoA synthase and malate dehydrogenase exist as multiple isoforms in this microalga, therefore, we first identified those implicated in the glyoxylate cycle based on the observation that lack of isocitrate lyase (ICL) in a previously identified icl deficient mutant was correlated with specific loss of the other enzymes of the glyoxylate cycle.
Although some alternate mRNA processing events are conserved between species, it has been suggested that a significant number of genes which are known to be alternatively processed in man, do not produce multiple isoforms in rodents [15].
We therefore conclude that while CTCF is expressed as a single transcript in human testis and cancers, BORIS is expressed as multiple isoforms in the testis, ES cells and in cancer cell lines, specifically in cells with increased DNA hypomethylation.
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Hence, in our study, a single transcript might be present redundantly as multiple isoforms or in multiple fractions and some of the transcripts might have been lost during the assembly due to low coverage.
These results confirmed that the multiple isoforms observed in tumor samples exhibited a prevalence associated with differential N-linked glycosylation (Fig. 6A and B).
CKI is a kinase with multiple isoforms implicated in Wnt signaling, nucleo-cytoplasmic shuttling, DNA replication, and DNA repair pathways.
A gene may have multiple isoforms expressed in the samples, but only one isoform is extracted by solving the above LP/ILP problem.
Another interesting property of this unprocessed pseudogene is that it shows alternative splicing there appear to be multiple isoforms represented in the reads covering the pseudogene locus.
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