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The authors examine ways in which modulation of multiple ion conductances can lead to the generation of this type of hyperexcitability.
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Our previous study demonstrated that multiple ion channels were heterogeneously expressed in human cardiac fibroblasts, including a large-conductance Ca2+-activated K+ current (BKCa), a volume-sensitive chloride current (ICl.vol), and voltage-gated sodium currents (INa).
Voltage-gated ion conductances were also characterized.
Further, voltage-dependent and -independent single channel ion conductances have been measured for annular Aβ oligomers.
Analysis of conductance-based neuron models reveals that temperature compensation of spike generation can be achieved solely relying on cell-intrinsic processes and despite a strong dependence of ion conductances on temperature.
State of electrolyte and ion conductance influenced significantly performance of ion battery [2].
Nevertheless, the YnaIK161A mutant only results in the increase of ion conductance but no variance in ion selectivity (Fig. 3C).
Recent work on molecular simulations of the mechanisms of lithium ion conductance has pointed towards two types of limiting process.
Ion conductance was measured by the 'dip-tip' technique [51].
Their functional partition is far richer than that reflected by their ion conductance properties [39].
Alternatively, it was also shown that this mutation can modulate the potassium ion conductance by Kir6.2 [21].
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