Sentence examples for multiple ion channels from inspiring English sources

Some investigational agents are directed at multiple ion channels, or are designed to be analogs of amiodarone.

In this model we considered the ATP release process and the activities of multiple ion channels and purinergic receptors.

Our previous study demonstrated that multiple ion channels were heterogeneously expressed in human cardiac fibroblasts, including a large-conductance Ca2+-activated K+ current (BKCa), a volume-sensitive chloride current (ICl.vol), and voltage-gated sodium currents (INa).

However, general anaesthetics act on multiple ion channels, receptors, and cell signalling systems in the central nervous system to produce anaesthesia, so it should come as no surprise that they also have non-anaesthetic actions that range from beneficial to detrimental.

We found that multiple ion channels were heterogeneously expressed in human cardiac fibroblasts.

Using these techniques, we identified multiple ion channels expressed in cultured human cardiac fibroblasts.

Moreover, STX1A also interacts with and co-regulates multiple ion channel types and neurotransmitter transporters (e.g., sodium ENaC, potassium KCNB1, and dopamine DAT; Table S7).

In summary, the present study provides the first information that multiple ion channel currents are present in cultured human cardiac fibroblasts, the patterns and properties of these ion channel currents differ from those observed in human cardiac myocytes.

These tissue models have been used to study the effects of single and multiple ion channel blockade on Purkinje fibers.

We collected multiple ion channel data (hERG, Na, l-type Ca) on 31 drugs associated with varied risks of TdP.

Cardiac myocytes have multiple ion channel types (see Fig.  1), and the human channels of each type can be studied in isolation in cells overexpressing single types.