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This approach would facilitate more thorough assessments by multiple investigators using several different models and increase our knowledge of the mechanism of action and efficacy of new compounds.
Taken together, data from multiple investigators using different model systems have found that SIN3 is necessary for regulation of key metabolic processes.
The resolution to this controversy will likely require larger scale studies by multiple investigators using identical chemical dosing and delivery protocols, in identical strains of immunocompetent and immunodeficient mice.
The results presented here represent the first attempt by an integrated consortium of independent labs to determine whether the effects of well-characterized ENMs on pulmonary responses in mice and rats could be reliably reproduced by multiple investigators using a harmonized protocol.
Similar(56)
Several investigators using multiple mammalian species have demonstrated that optimal in vitro initiation of forward motility in the immature caput-sperm requires four exogenous parameters: theophylline, epididymal plasma, bicarbonate, and alkaline pH [27].
However, multiple investigators were used in the scoring, one without any knowledge of application.
Only after multiple trials are completed by several groups of investigators using differing methodologies produce concordant results whether it should be believed that the findings are well supported and are to be used in the practice.
The chicken-specific techniques will be of highest interest to investigators using avian embryos, development and packaging of lentiviral vectors that reliably express multiple proteins in infected cells should be of interest to all investigators whose experiments demand manipulation and expression of multiple proteins in developing cells and tissues.
Some investigators use multiple tests to examine multiple candidate cut-points and adjust their P values.
Investigators used multiple glycemic medications in both arms.
Investigators use a common conceptual framework based on multiple levels of biologic, behavioral, and social organization across the life span.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com