In 2011, a multicenter, randomized, single-blind, placebo-controlled phase 1/2a study assessed the safety and tolerability of GSK933776 after single and multiple dose intravenous administration in 44 subjects with mild to moderate AD, of whom 33 were exposed to the active compound [ 9, 31].
Previously, it was shown that administration of multiple intravenous (i.v).v
Repeated intravenous administrations or protracted infusions are heavy for patients.
In our opinion, transtympanic and intravenous administrations have different indications.
One case presented with multiple organ dysfunction and the intravenous administration of ascorbate resulted in improved cardiovascular functioning within 24 h, particularly increased arterial pressure, decreased heart rate, normalised central venous pressure and a decreased need for catecholamines [ 35].
To induce insulin-dependent diabetes, STZ is typically given through a single intravenous administration or through multiple low-dose intraperitoneal administrations (Deeds et al., 2011).
Those studies with the EU-approved originator as a comparator demonstrated similarity across doses ranging from 1 10 µg/kg in both single-dose and multiple-dose settings for subcutaneous and intravenous administration.
Intravenous administration and oral ingestion of multiple amino acids are known to modulate insulin secretion acutely (30, 31); however, such effects have not been reported for fasting amino acid levels in prospective settings.
Antibiotic prophylaxis is based on intravenous administration of 1 g cefazolin, with the multiple-dose regime consisting of 4 perioperative doses.
Intravenous administration of nicotinamide riboside or mononucleotide delivered intact molecules to multiple tissues, but the same agents given orally were metabolized to nicotinamide in the liver.
