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Nitrosative stress caused by PABA/NO does not cause high levels of stable cysteine nitrosylation [3], but instead leads to S-glutathionylation of multiple intracellular proteins [6], [8].
The proteasome is a multicatalytic protease complex responsible for the degradation of multiple intracellular proteins that are involved in various cellular events, including DNA repair, cell cycle, survival and apoptosis.
NMDARs are heteromeric ligand-gated ion channels that interact with multiple intracellular proteins through different subunits.
This Leishmania surface protease cleaves multiple intracellular proteins and participates in p38 mitogen-activated protein (MAP) kinase inactivation (Hallé et al., 2009).
Cells undergoing TRAIL-induced death show many of the hallmarks of apoptosis, including DNA fragmentation, expression of pro-phagocytic signals on the cell membrane and cleavage of multiple intracellular proteins by caspases (Griffith et al, 1998).
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We note that multiple intracellular protein fragments are routinely identified from human plasma [ 34, 42, 55, 56] and FF [ 21, 31].
They can regulate multiple intracellular signaling proteins involved in cell proliferation and differentiation and have important roles in mitogenic and antiapoptotic function of nicotine [ 49, 50].
ECM adhesion is generally mediated by integrins, transmembrane receptors connecting the ECM to the actin cytoskeleton via multiple intracellular linker proteins [ 1, 2].
Platelet adhesion also initiates multiple intracellular G protein-coupled signalling pathways (Fig. 1b).
Sunitinib is another oral small molecule inhibitor that targets multiple intracellular and receptor protein kinases, including VEGF and PDGF receptors, c-Kit, and rearranged during transfection (RET).
Activation of TLRs engages multiple intracellular adaptor and signaling proteins and triggers several cascades of innate immune response [17].
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multiple extracellular proteins
multiple intracellular compartments
multiple soluble proteins
multiple intracellular roles
multiple intracellular effectors
multiple intracellular responses
multiple intracellular peptides
multiple intracellular processes
multiple intracellular caspases
multiple intracellular activities
multiple intracellular aggregates
multiple intracellular substrates
multiple intracellular regions
multiple intracellular locations
multiple intracellular pathways
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