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Whereas this study examines project-level decisions on one specific intervention, the approach is equally relevant to address decision-making for multiple interventions, at multiple scales, and for multiple criteria (e.g., across ecosystem services), and thus is an important tool that can support linking knowledge with action.
Most clinicians support an approach of multiple interventions at different dimensions, customized to the individual patient.
Moreover, experimental designs do not allow the simultaneous evaluation of multiple interventions at the levels of the health-care system and individual patient care.
The complexity of addressing symptomology of depression together with predominantly socio-economic causes suggests the need for multiple interventions at various levels of the problem.
Indeed, evidence from tobacco control suggests that comprehensive strategies involving multiple interventions at multiple levels may be more powerful than narrower approaches [ 84, 85].
A major limitation of this study is the use of multiple interventions at the same time in both arms, making it difficult to discern which one of these interventions causes benefit.
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With multiple interventions employed at the same time, it is difficult to discern which form of feedback was most responsible for the change in behavior.
Throughout the previous decade, multiple interventions aimed at patients and clinicians have been implemented to promote appropriate antimicrobial drug use and prevent the development of antimicrobial resistance.
Future research may also seek to examine if multiple interventions provided at different points in training may serve as a buffer during these transition times.
Finally, the design can reduce the total number of participants required to assess the multiple interventions aimed at achieving the same outcome (Montgomery et al, 2003; Gurusamy et al, 2011).
However, our static model, like others, 39, 40 avoids having to estimate uncertain and unknown parameters required for dynamic models that explore the impact of multiple interventions introduced at various stages over time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com