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Factorial designs are highly efficient (permitting evaluation of multiple intervention components with good statistical power) and present the opportunity to detect interactions amongst intervention components.
Factorial designs allow researchers to examine whether multiple intervention components affect hypothesized change mechanisms, and whether the affected mechanisms are related to cessation.
The Multiphase Optimization Strategy (MOST) uses highly efficient factorial experiments to evaluate multiple intervention components for possible inclusion in an optimized tobacco use treatment.
In studies in which multiple intervention components were part of the adherence-enhancing intervention, each intervention component was reported with a different frequency.
The loneliness intervention described in this manuscript distinguishes itself from others by including multiple intervention components and targeting individuals and their environment.
Each campaign is composed of at least one intervention distribution event, although most realistic campaigns will be composed of multiple intervention components repeated at intervals.
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Factorial experiments permit analyses of the influence of patient characteristics on main and interaction effects of multiple, relatively discrete, intervention components.
Finally, based on experiences in other community interventions [ 34- 36], an integrated approach was initiated, combining multiple strategies; delivering intervention components to different target groups and in different settings; and influencing a range of outcomes, i.e. it is a complex intervention [ 37, 38].
These characteristics provide the essential strength as well as weakness, as they increase the risk of variance, due to the number of intervention components, the multiple interventionists, and the heterogeneity of the group of geriatric patients [ 6, 17].
In the other studies, which included patients with any combination of conditions, the focus tended to be on older patients and the interventions had multiple components, making comparison between studies and between intervention components difficult.
Two studies included multiple interventions in one CCM component, three studies included interventions covering two CCM components, five studies covered three components and one study [ 36] included interventions from 4 CCM components.
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multiple intervention efforts
multiple intervention interactions
multiple intervention sets
multiple intervention arms
multiple intervention types
multiple intervention trials
multiple intervention activities
multiple intervention possibilities
multiple intervention groups
multiple intervention strategies
multiple intervention studies
multiple intervention methods
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