Similarly to what we described above for apoptosis, the ability of BAG3 to regulate cell adhesion appears to rely on multiple interactions of this protein through different structural domains.
The outcome of cancer progression depends on multiple interactions of cancer cells with various host factors; that is, the interaction of tumour cells with the organ environment modulates the tumorigenic properties by regulating their phenotypes, such as cell proliferation, motility and invasion (Fidler, 1990).
Thus, it should be possible to get multiple interactions both on the acceptor and donor side.
Integrin α4 β1 expressed on erythroblasts mediates multiple interactions via binding with VCAM-1 on the central macrophage and ICAM4 on neighboring erythroblasts [ 32, 33].
The process of cancer metastasis depends on multiple interactions between cancer cells and host cells.
Note that multiple interactions detected among loci on the same linkage groups were counted as a single interaction, accounting for the non-independence of these loci due to linkage.
Given that the gut brain axis depends on multiple interactions between peripheral and central signals, and because these signals are interdependent, it is crucial to have a holistic view about dietary sugar effects on health.
This gene's SNP shows a modest P-value (>1e-4) for association by single SNP analysis [ 3]; therefore, the disease association of this SNP is dependent on multiple interactions with other loci.
Furthermore, while patients wait-related satisfaction was typically based on multiple interactions with different providers, positive or negative experiences with a single provider, often (but not always) the family physician, had a substantial impact on the overall satisfaction or dissatisfaction with wait time experiences.
A new model that couples both the near-surface cascade of the hot liquid metal and the effect of multiple interaction mechanisms on the binding of the emitted particle explains this anomalous erosion enhancement with target temperature.
