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Many target proteins interact with a number of different partners and may possess multiple interaction sites.
Cellular and binding assays identify overlapping Wnt3a- and Dkk1-binding surfaces on the third PE pair, consistent with steric competition, but also suggest a model in which the platform structure supports an interplay of ligands through multiple interaction sites.
For TP5, it contains Val and Tyr residues which belong to basic anchor motifs, providing multiple interaction sites.
TSAd is known to interact with the Src kinase Lck [15] through the Lck SH2- and SH3-domains [22] via multiple interaction sites [20].
Attempts to map the interaction region in the S protein in more details by co-immunoprecipitation and yeast two-hybrid system were unsuccessful, due to the presence of multiple interaction sites.
The multiple interaction sites leading to ORAI1 activation might involve a conformational rearrangement within STIM1.
Similar(45)
It is thought that the presence of multiple miRNA interaction sites allows for exquisite control of target mRNA expression [ 47].
As suggested by the reviewers we have also constructed a p62 version with multiple LC3B interaction site (LIRs).
In order for a drug to bind to multiple targets, the interaction sites of these targets must be similar on a molecular level.
In heparin-treated eggs, we found that Ca2+ waves evidently initiated at multiple sperm-egg interaction sites (Fig. 2A, lower panel).
PPS molecules composed of 11 or more saccharide units were 100-fold more effective than those of eight saccharide units, indicating the involvement of extended or multiple protein-interaction sites.
More suggestions(15)
multiple interaction possibilities
multiple interaction mechanisms
multiple interaction models
multiple interaction blocks
multiple interaction mixtures
multiple interaction networks
multiple interaction modes
multiple interaction instances
multiple interaction surfaces
multiple interaction contexts
multiple interaction elements
multiple interaction observations
multiple interaction channels
multiple interaction motifs
multiple interaction datasets
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