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Loci causing male sterility in Drosophila pseudoobscura Bogota USA hybrids also have multiple interaction partners; seven loci of varying effect size interact to cause sterility (Phadnis, 2011).
Nbs1 has FHA and BRCT domains to bind multiple interaction partners that further regulate MRN.
We further examined the characteristics of IRs displaying multiple interaction partners in the IVV experiment (Figure 3).
The flexibility observed in the putative protein binding groove may enable SnoN to recognize multiple interaction partners.
Rather, domain shuffling allows the rapid generation of multiple interaction partners.
In line with the features of intracellular IDPs, extracellular structural disorder is heavily post-translationally modified and involved in extensive interactions that organize large molecular assembles while binding multiple interaction partners.
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Along with multiple known interaction partners we identified novel candidates including proteins that had already been linked to ciliary function.
Complex formation is one of the typical patterns in this graph and many cellular functions are performed by these complexes containing multiple protein interaction partners.
Several variants of this approach exist: correcting for the underlying speciation signal has been reported to improve accuracy [ 25, 26], incorporation of phylogenetic information in addition to distance matrices has been used to aid supervised learning for prediction of protein-protein interactions [ 27] and multiple interacting partners have been included [ 28].
Intrinsic disorder does not imply a lack of structure, but rather allows these regions to function as binding surfaces with multiple interacting partners; IDPs are often hubs in protein protein interaction networks (Cumberworth et al., 2013).
All five domains appear to function as protein interaction modules mediating associations of SAP scaffolds with their multiple interacting partners [11].
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various interaction partners
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multiple interaction mechanisms
multiple interaction models
multiple interaction mixtures
multiple interaction blocks
multiple interaction modes
multiple interaction networks
multiple interaction surfaces
multiple interaction instances
multiple interaction sites
multiple interaction contexts
multiple interaction elements
multiple interaction observations
multiple interaction channels
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