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Several variants of this approach exist: correcting for the underlying speciation signal has been reported to improve accuracy [ 25, 26], incorporation of phylogenetic information in addition to distance matrices has been used to aid supervised learning for prediction of protein-protein interactions [ 27] and multiple interacting partners have been included [ 28].
Intrinsic disorder does not imply a lack of structure, but rather allows these regions to function as binding surfaces with multiple interacting partners; IDPs are often hubs in protein protein interaction networks (Cumberworth et al., 2013).
The most highly ranked component duplicated gene interaction network involves defects in CALM1 and its multiple interacting partners that are important in regulating voltage-independent calcium-activated action potentials at the neuronal synapse.
These findings suggest that, at the level of atomic structures, protein protein interactions are precisely designed; hence, protein interfaces with multiple interacting partners should involve incompletely overlapping multiple interfaces and/or accommodate structural changes upon binding to their targets.
All five domains appear to function as protein interaction modules mediating associations of SAP scaffolds with their multiple interacting partners [11].
Furthermore, in a complex biological system in which multiple interacting partners are present, the effect exerted by a ligand also depends on binding selectivity, i.e., the relative binding affinity toward a target when compared to other proteins.
Similar(49)
For SodB that has been identified as a factor in F. tularensis oxidative stress protection [ 71], we found multiple potential interacting partners, including interactions with the murine thioredoxin-interacting protein Txnip, a protein mediating oxidative stress via thioredoxin activity [ 72].
Indeed, we hypothesize that Tspan9 has multiple simultaneous interacting partners and functions as an interaction 'hub' within tetraspanin microdomains.
Loci causing male sterility in Drosophila pseudoobscura Bogota USA hybrids also have multiple interaction partners; seven loci of varying effect size interact to cause sterility (Phadnis, 2011).
Thus, as in rodents and primates, prominin-1 from non-mammalian vertebrate animal models has the same propensity to appear in various alternatively spliced forms being suggestive of multiple — yet unidentified — interacting partners and/or specific functions.
Alpha-actinins are important cytoskeletal proteins with multiple roles and many interacting partners.
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