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Proteins, DNA, and RNA have all been used to construct "scaffolds" that co-localize multiple interacting molecules by assembling them into a single physical complex, enhancing interaction rates.
The joint sequence space of multiple interacting molecules contains more dimensions and therefore far more paths between functional joint genotypes than does either molecule's separate sequence space (Gavrilets, 2004).
Similar(58)
Atherosclerosis involves the interplay among thousands of molecules in multiple interacting cells types including macrophages, endothelial cells and smooth muscle cells (SMCs).
This result further demonstrated that D-CblL down-regulates EGFR through multiple mechanisms, and other D-CblL interacting molecules besides Drk might play important roles in down-regulating EGFR signaling even when Drk is absent.
Multiple interacting systems can be designed with separation of concerns.
Nevertheless, we cannot exclude the involvement of other interacting molecules.
Relation (15) holds only for a pair of interacting molecules.
Some of these included cell-surface proteins, including adhesion molecules and other cell-cell interacting molecules.
As a physiologically-relevant measure of the force production in the purified actomyosin system, an optical trap assay was used to measure the stall force of multiple myosin molecules interacting with an actin filament [10].
Although the methodology may be easily extended to include the prediction of ligands that interact with multiple protein molecules, for simplicity we only considered structures in which the ligand interacts with a single protein molecule.
A comprehensive understanding of how MADS domain proteins interact with multiple molecules in a concerted manner would provide a significant advance in understanding the molecular basis of the wide range of developmental mechanisms in which these proteins participate.
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