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With respect to the substrates of tyrosine phosphorylation and Crk transformation, a great deal of attention has been placed on the p130Cas/HEF1/Efs proteins, a family of non-enzymatic docking proteins that contain multiple interacting domains and serve as important anchoring points for protein-protein interactions [ 46, 91].
A larger protein comprising multiple interacting domains will have a higher chance to evolve high connectivity.
Many MT binding proteins have multiple interacting domains such as CC and PR, allowing them to partner with different proteins in a mutually exclusive and/or competitive fashion (for reviews, see Akhmanova and Steinmetz, 2008; Akhmanova and Steinmetz, 2010).
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The multiple protein protein interacting domains in Tjps allow for many interacting partners and facilitate formation of large complexes in proximity of cell membranes that are associated with tight, adherens, and gap junctions.
The presence of a membrane anchor at position C739 can be expected to influence the tilt of multiple interacting transmembrane domains in NCX1 (52).
Marshalin exhibits multiple protein interacting domains including a CKK domain (DUF1781) at the C-terminus, a calponin homology (CH) domain at the N-terminus, and three coiled-coil (CC) and two proline-rich (PR) domains in the middle (Fig. 1C).
Based on this extended perspective, we address in this paper how support technologies (should) impact the coordination of work across multiple agents, controlling a dynamic domain with multiple, interacting processes.
All five domains appear to function as protein interaction modules mediating associations of SAP scaffolds with their multiple interacting partners [11].
Multiple interacting systems can be designed with separation of concerns.
Overlapping interacting domains were further merged together.
Number of protein-protein oncogenic interacting domains.
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