Sentence examples for multiple integration events from inspiring English sources
Therefore, the second BamHI site of the BamHI fragments must be located within the genomic sequence flanking the integrated plasmid, and detection of more than one BamHI hybridization signal indicates multiple integration events in different areas of the genome.
Our results clearly show that incubation with the INr peptides stimulate viral DNA integration leading to multiple integration events.
We demonstrate kDNA minicircle sequences concentrated within LINEs, and multiple integration events mobilizing, and thus 'hitchhiking', to other chromosomes, resulting in disruption of coding regions and gene loss.
Expression of RB is closely correlated with the resistance phenotype and transgenic plants with multiple integration events are typically more resistant than those with fewer copies of RB [33], [34].
Given the reported continued transposition activity of IS100 [17], we postulated that the particular IS100 copies were due to duplicated translocation or multiple integration events of this element occurred within this strain.
Three cell clones (C-6, -7, and -8) contained multiple XMRV proviruses, which may have resulted from multiple integration events within the same cell clone or from mixed clonal populations.
By contrast, plasmid integration (ends-in gene targeting) is often associated with multiple targeted integration events but illegitimate integration is extremely rare and a targeted chromosome duplication has not been reported.
Note that use of crude (low-titer) rAAV lysates is thought to lead to a very low probability of multiple genomic integration events in the same cell [36].
Remarkably, we were able to detect multiple independent integration events in 21 28% of tagged genes from control fish when the constitutive ß-actin:SB11 transgene was used as the transposase source.
They could result from a single integration event, the phage DNA being duplicated by an uncharacterized DNA repair and/or replication event, or from multiple successive integration events.
While others may have been derived from multiple independent integration events, as no similarity was observed among their flanking genomic sequences (see Additional file 1: Figure S6).
