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Each control module receives multiple inputs in the form of the incident transcription factors which bind to them.
The numerous domains that are present in many Dbl family proteins suggest that they act to integrate multiple inputs in complicated signaling networks involving the Rho GTPases.
These results also underscore the importance of tight regulation of the IP3 signaling cascade, and demonstrate how IP3 signaling can be modulated at multiple inputs in the pathway.
This complex signaling pathway involving the three kinases PI3K, Akt, and mTOR, integrates multiple inputs in order to promote cell growth and proliferation [ 66].
The pipelines are running in Ergatis [ 5]: a workflow management system able to iterate through multiple inputs in order to run them at the same time on a computer farm.
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Dutch neurosurgeon Willem Noordenbos extended the theory of pain as an integration of multiple inputs into the nervous system in his short but classic book, Pain (1959).
We believe that interactions between signaling pathways, so called molecular cross-talk, enables the cell to process and interpret multiple inputs differently in different contexts.
There are also examples of riboswitches with two different aptamers that allow integration of multiple inputs as in the metE riboswitch [ 67].
A reaction usually contains multiple inputs and outputs, in addition to catalysts, inhibitors and activators.
Ability to handle multiple inputs and outputs in different units of measurement is the main explanation for this [ 20].
The DEA approach to frontier estimation has been argued to accommodate multiple inputs and outputs in a single measure of efficiency unlike the Stochastic Frontier Analysis SFAA) which cannot [ 29, 30].
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