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In the spinal dorsal horn of young animals, as used in this study, glycine-only, GABA-only, and mixed GABA/glycine IPSCs were recorded [ 21, 22], suggesting that the mIPSCs recorded in this study are also composed of postsynaptic currents mediated by these multiple inhibitory transmitters.
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Nevertheless, there is enough evidence that some amino acids act as either excitatory or inhibitory transmitters.
Levels of inhibitory transmitters increase sharply, and levels of many activating messengers drop, or shut down entirely.
Blackburn, S. D. et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.
Blackburn, S.D. et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.
Finally, DE-anorexia generates multiple inhibitory processes to suppress feeding.
The multiligand functionality of RAGE also suggests multiple inhibitory effects of GA on other ligands.
This may be especially true where gap junctions are used in combination with inhibitory transmitters [48].
Both anatomical [34] [38] and physiological [12], [39] [42] findings provided evidence for a role of these inhibitory transmitters in modulating synaptic transmission, e.g. in response to certain stimulus configurations.
Also neurons exhibiting multiple inhibitory areas can be considered as reflecting local inhibitory influences [22].
The mechanism through which esmolol facilitates the release of inhibitory transmitters remains unidentified.
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