Sentence examples for multiple inhibitory epitopes from inspiring English sources
The changes made between mutants 15 and 17 and then to hTNFα all contribute to an increased sensitivity to AZD9773, suggesting multiple inhibitory epitopes.
The MSP-119 mutant proteins with single substitutions at positions 22 (Leu → Arg), 43 (Glu → Leu) and 53 (Asn → Arg) and the MSP-119 mutant protein with multiple substitutions at positions 27 + 31 + 34 + 43 (Glu → Tyr, Leu → Arg, Tyr → Ser, Glu → Leu); which had inhibitory epitopes; had the highest recognition.
Finally, DE-anorexia generates multiple inhibitory processes to suppress feeding.
The multiligand functionality of RAGE also suggests multiple inhibitory effects of GA on other ligands.
Mapping of human FVIII inhibitors in haemophilia A or autoantibody origin have delineated three major clusters of B-cell inhibitory epitopes (domain A2, A3 and C2).
A further consideration is that the polyclonal antibody response to merozoite antigens includes inhibitory and non-inhibitory antibodies; repeated exposure may lead to non-inhibitory antibodies reaching a greater concentration or higher affinity than inhibitory antibodies, especially if inhibitory epitopes are fewer in number than non-inhibitory epitopes.
Also neurons exhibiting multiple inhibitory areas can be considered as reflecting local inhibitory influences [22].
However, inhibitory antibodies were not elicited to three other VAR2CSA-DBL4 recombinant proteins produced in the same Baculovirus system [42], [43], suggesting that inhibitory epitopes may be poorly immunogenic or difficult to recapitulate with single domain immunogens.
Although women exposed to placental infections acquire antibodies that block adhesion of geographically diverse placental isolates [5], the specific targets of inhibitory antibodies remain unknown and inhibitory epitopes appear to be at least partially strain-dependent [30] [32].
These observations suggest possible activation of multiple inhibitory systems.
It is clear from Figure 6 that there is significant overlap between the inhibitory epitopes and those parts of TNFα thought to interact with the TNF receptors.
