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The multiligand functionality of RAGE also suggests multiple inhibitory effects of GA on other ligands.
These studies have demonstrated multiple inhibitory effects on APC function by HIV virions or specific HIV products.
In these cases, the cell death can be the result of multiple inhibitory effects.
Together, these results show that miRNA-mediated repression of target mRNA is cap-dependent and results from multiple inhibitory effects on translation initiation.
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However, acetylcholine obviously has multiple effects (including inhibitory effects) on DA neuron excitability, depending on the concentration of synaptic acetylcholine and its duration of action (Fiorillo & Williams, 2000).
Although the exact mechanism by which IL-10 exerts its effect in the tumour microenvironment is unclear, it is accepted that this cytokine has multiple stimulatory and inhibitory effects on innate and adaptive immune responses respectively.
By their capacity to bind surface nucleolin in the 500-kDa protein complex, we show that HB-19 and related multivalent Nucant pseudopeptides exert multiple and distinct inhibitory effects on cell proliferation, adhesion, spreading, inflammation, and cell death.
These results show that top-down signals are generated at each level of the visual hierarchy, that a single area can receive top-down influences from multiple levels, and that inhibitory effects are seen only in top-down and lateral coupling.
Considering its strong inhibitory effects against multiple kinases activation in CRC cells observed in our study, it seems plausible to hypothesize that ursolic acid may also play a neuroprotective role against oxaliplatin-induced neuropathy while enhancing its cytotoxicity against tumor cells.
Multiple studies have shown the inhibitory effects of individual inflammatory factors (such as TNF-α, IFN-γ, IL-6) on proliferation but variable effects on maturation [reviewed in 41].
Thus, multiple mechanisms may explain the inhibitory effects of MTX on inflammatory bone destruction.
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