Sentence examples for multiple inhibitors in from inspiring English sources

Both are clinically validated targets with multiple inhibitors in therapeutic use.

PTEN downregulation decreases not only sensitivity to endocrine therapy, but also sensitivity to the kinase inhibitors, perhaps due to the multiple feedback loops active in this complex network that may require multiple inhibitors in combination to overcome [ 53, 54].

Overexpression of Aurora kinases A and B have been linked to genetic instability and are frequently overexpressed in solid tumors such as colorectal cancer [ 50, 51] and inhibition of aurora kinases has become an attractive therapeutic strategy with multiple inhibitors in clinical development.

Parenthetically, we tried multiple JNK inhibitors in-vivo and were unable to consistently obtain pharmacodynamic evidence for specificity and in-vivo action.

As shown in Fig.  6, ROS accumulation was detected both in the parental strain and recombinant strains after the addition of FAP, reflecting that the multiple inhibitors might cause oxidative stress in yeast strain.

We first aimed at obtaining a strain with extremely high performance in terms of growth and fermentation directly in inhibitor-rich lignocellulose hydrolysate, since simultaneous tolerance to multiple inhibitors is important for high productivity in lignocellulose hydrolysates [ 28].

(a) The strains were cultivated in YPD medium in the absence of multiple inhibitors.

The predicted targets important for strain resisting multiple inhibitors (furfural, acetic acid and phenol) in S. cerevisiae.

In other cases, multiple inhibitors and receptor blockers were used, and the final eicosanoid product mediating an effect was identified.

This was not completely expected and can be explained either by the presence of multiple inhibitors with distinct or overlapping specificities in PJ-S21 or by induction of gp120 conformational changes [ 54] resulting in blockade of both CD4 and CXCR4/CCR5 binding sites on gp120.

First, in a dilute mixture with multiple inhibitors, the partitioning calculation, to first approximation, is independent for each inhibitor species.