Sentence examples for multiple inhibitors and from inspiring English sources

Although the numbers of BFU-E colonies arising from inhibitor-treated Mtf2 KD HSPCs was still lower than that observed from control cells, the rescue of erythroid differentiation to the BFU-E stage was robust and observed using multiple inhibitors and shRNA clone combinations.

In other cases, multiple inhibitors and receptor blockers were used, and the final eicosanoid product mediating an effect was identified.

JBU has a bound phosphate and covalently modified residue (Cys592) by β-mercaptoethanol at its active site, and the concomitant binding of multiple inhibitors (phosphate and β-mercaptoethanol) is not observed so far in bacterial ureases.

The predicted targets important for strain resisting multiple inhibitors (furfural, acetic acid and phenol) in S. cerevisiae.

Yet the clinical development of therapies targeting the FGFR signalling pathway presents multiple challenges, with diverse mechanisms of pathway activation combined with multiple inhibitors of differing potency and with antibodies in preclinical development.

The picture that emerges is that activation of FGF signaling induces the production of multiple inhibitors which act to moderate and limit the response to FGF signaling.

Multiple inhibitors targeting PI3K, AKT, RAF and MEK are under development for cancer therapy, but early-phase clinical trials suggest that the single agent efficiency of such inhibitors seems to be limited, except in the case of the Raf mutant melanoma, where both RAF and MEK inhibitors have high clinical activity.

Multiple inhibitors upstream of SQLE, such as fluvastatin and atorvastin inhibiting HMGCR16 and lapaquistat inhibiting squalene synthase17, did not display a similar sensitivity profile to NB-598 (Fig. 5h).

In addition, a new selection was carried out with a slightly longer pool (N62) in order to identify aptamers that might cover larger swaths of the NgR surface and thereby prevent binding of multiple inhibitors.

To estimate inhibitory effects of the hydrolysate, response surface methodology was utilized to analyze cell growth and PHA accumulation in the presence of multiple inhibitors.

The synthetic strategy was designed modularly to access multiple inhibitors with different aryl functionalities containing both the natural depsipeptide and peptide isostere variant of the macrocycle.