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We also tested differences of genotypes between groups by analysis of multiple inheritance models but they were not statistically significant (Table 3).
The significance of the differences of observed alleles, genotypes and haplotypes between groups as well as analysis of multiple inheritance models (codominant, dominant, recessive, overdominant, and log-additive) were also tested using SNPStats (http://bioinfo.iconcologia.net/snpstats/start.htm).htm
SNPstats provides genotype frequencies, proportions, odds ratios (OR) and 95% confidence intervals (CI), and p-values for multiple inheritance models.
Furthermore, single SNP analyses were performed using multiple inheritance models, namely, additive, dominant, and recessive models, similarly to an earlier study [ 15].
The significance of the differences of observed alleles and genotypes between groups, as well as analysis of multiple inheritance models (co-dominant, dominant, recessive, over-dominant and log-additive) for SNPs were also tested using a free web-based application (http://213.151.99.166/index.php?module=Snpstats) designed from a genetic epidemiology point of view to analyze association studies.
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We assumed a multiplicative inheritance model by performing logistic regression.
This is very significant because (1) they have been reported in large studies that included replication in independent samples [ 22, 23], and (2) our study is of sufficient power, we performed analyses for multiple inheritance and interaction models and we used the most powerful tests [ 15, 16].
Figure 8 illustrates an example of multiple inheritance in the Gene Ontology.
On one hand, multiple inheritance facilitates the creation of compact and easily navigable models.
Addressing these issues requires quantitative modeling, and eventually the integration of multiple inheritance systems with their different characteristics into population genetics.
Multiple inheritance can be more easily spotted and understood using graphical models and, in many cases, it can be avoided by replacing one (or more) Is_a relation(s) by other types of relations, thus eliminating this problem.
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