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Few banks can use advice about navigating the federal government more than Citigroup, a company so hobbled by the crisis that it has essentially become a ward of the state, kept alive through multiple infusions of taxpayer funds.
Multiple infusions of CAR-T cells is also an effective option for patients who experienced CD19 positive relapse (Maude et al., 2014a; Kochenderfer et al., 2012, 2015).
These additional restimulations may be necessary in scenarios in which there is only limited amount of starting Tregs (cord blood) or when multiple infusions of Tregs will be necessary to observe a therapeutic effect.
Of note, multiple infusions of Th2.R cells (both day −7 and day 0) prior to transplantation resulted in a decrease in IFN-γ secretion relative to recipients of a single dose Th2.R cells.
In that observational study, which was specifically designed to evaluate safety, normothermic hypoproteinemic patients at 14 US hospitals received multiple infusions of 80 to 100 mL of 25% albumin over a maximum period of 570 days.
The PK parameters following the first infusion and multiple infusions of olaratumab at 10 mg/kg q3w (cohort 1), 15 mg/kg q3w (cohort 3), and 20 mg/kg q2w (cohort 2) are summarized in Table 4.
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However, a major disadvantage to passive immunization for chronic neurodegenerative disorders would be the need for multiple infusions and the risk of developing anti-idiotypic immunity, which would limit efficacy and be associated with toxicity.
Robust standard error estimates were obtained to account for the occurrence of multiple infusions per patients.
Alternative strategies with similar or better therapeutic efficacy without the inconvenience and risks of multiple infusions are desirable.
We suspect that this finding could be explained by an increase in units infused per bleed over time, due both to the increased practice of giving multiple infusions per bleed, and the increase in vial sizes.
Critically ill patients in the intensive care unit (ICU) usually receive multiple infusions simultaneously, which increases the likelihood of pump-related errors.
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