Sentence examples for multiple inflammatory genes from inspiring English sources
It forms a major AP-1 DNA binding protein and participates in the regulation of multiple inflammatory genes in gastric epithelial cells [16].
Indeed one sequence, UUAUUUAUU, found in the Themis2 3'UTR represents the cognate binding site for TTP [47], a post-transcriptional regulator induced by inflammatory stimuli and implicated in the control of the expression of multiple inflammatory genes [48].
Because genetic associations of disease and genetic variations in inflammatory genes are often relatively modest, it is likely that polymorphisms in multiple inflammatory genes cooperate in an additive or synergistic manner to impact disease risk.
The transcription factor NF-κB plays a prominent role in the activation of multiple inflammatory genes in RA [ 15, 16].
Nuclear factor-κB plays a pivotal role in the coordinated transcription of multiple inflammatory genes and is a probable drug target.
PD5 animals also showed an upregulation of multiple inflammatory response genes and an activated NF-kB target pathway.
Through transrepression, the hGRα GC complex interacts with the activated by NF-κB and other pro-inflammatory transcription factors with intrinsic histone acetyltransferase (HAT) activity switching off multiple activated inflammatory genes (i.e., IL-6).
Nuclear factor kappa B (NF-κB) is a transcription factor that regulates the expression of multiple immune and inflammatory genes [ 6].
However, the complex regulation of the OPN gene in response to multiple inflammatory and steroid hormone promoter elements makes it challenging to predict the precise responses of the gene in vivo.
Mice with B. burgdorferi induced arthritis or carditis show increases in multiple inflammatory mediators including tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and interferon regulated genes such as, cxcl10 and ifit1 [13] [16].
A promoter polymorphism of the osteopontin (OPN) gene (rs28357094) has been associated with multiple inflammatory states, severity of Duchenne muscular dystrophy (DMD) and muscle size in healthy young adults.
