NF-κB activation is clearly linked to the pathogenesis of multiple inflammatory diseases including arthritis.
TNFα is a critical proinflammatory cytokine that is implicated in the pathogenesis of multiple inflammatory diseases.
Chronic oxidative stress is involved in the pathogenesis of multiple inflammatory diseases, including cardiovascular disease and atherosclerosis.
Our findings are consistent with elevated SCN− contributing to an enhanced risk of developing pathologies associated with multiple inflammatory diseases.
Minocycline and doxycycline are semi-synthetic tetracycline antibiotics with anti-inflammatory properties that are used to treat multiple inflammatory diseases, including rheumatoid arthritis (RA) [ 1, 2].
Especially, the IL-1 receptor has been selected as a functional target for multiple inflammatory diseases like rheumatic arthritis, in mouse models and human subjects [ 14, 15].
IL1 and CCL8 are prominent inflammatory cytokines implicated in multiple inflammatory diseases such as atherosclerosis, rheumatoid arthritis (RA) and Alzheimer's diseases [ 15, 16].
Such dual-function carriers have potential to enhance the overall therapeutic outcomes of gene therapy for multiple diseases in which CXCR4 plays a prominent role, including cancer metastasis, HIV infection, and multiple inflammatory diseases.
On this basis, iron chelation may be a suitable alternative to antibiotics in preventing multiple inflammatory diseases (and such chelation may be nutritional rather than pharmacological in nature, e.g. 183).
The inflammasome is a multiprotein complex that regulates the release of caspase (e.g., caspase-1 and caspase-11) -dependent cytokine (e.g., IL-1 β and IL-18) release, which contributes to multiple inflammatory diseases, including peritonitis.
Dysregulated PAD activity, most notably PAD2 and PAD4, is associated with multiple inflammatory diseases (e.g., rheumatoid arthritis) as well as cancer, and PAD inhibitors, such as Cl-amidine and BB-Cl-amidine, show efficacy in multiple preclinical animal models of disease.
