Sentence examples for multiple inflammatory cytokines from inspiring English sources

In addition, MTDs significantly induce the expression of multiple inflammatory cytokines and chemokines in the lungs, and miR-223 deficiency leads to increased cytokine release.

The innate immune system provides a first line of defense against invading pathogens by releasing multiple inflammatory cytokines, such as interleukin-1beta and tumor necrosis factor-alpha, which directly combat the infectious agent and recruit additional immune responses.

siRNA-mediated silencing of ZFP36 resulted in dramatically increased expression of multiple inflammatory cytokines, most of which were also increased in the plasma of chronic HBV patients.

Analysis of Notch mutant skin revealed an increased expression of multiple inflammatory cytokines and dermal infiltration of Th2 cells.

(ii) Blocking c-Rel suppresses the expression of multiple inflammatory cytokines and inhibits the growth of B cell tumors.

These results indicate that NYVAC-C-ΔB19R induced the expression of IFN-induced pathways and IFN-regulated transcription factors as well as multiple inflammatory cytokines.

O3 exposure elicits airway inflammation characterized by neutrophil accumulation (Schelegle et al. 1991; Seltzer et al. 1986) and liberates multiple inflammatory mediators, cytokines, and chemokines as an early inflammatory event (Aris et al. 1993; Koren et al. 1989).

The analysis revealed that synergistic action of the transcription factors AP-1, vitamin D receptor and Nuclear Factor-kappaB in cross-activation of multiple pathways, including inflammatory cytokines, complement, clusterin, ephrins, and multiple metabolic pathways.

Abatacept thus downregulates T-cell stimulation, leading to decreased B-cell and macrophage activation and to the modulation of multiple downstream inflammatory cytokine pathways that have been implicated in the pathogenesis of JIA.

NFκB is one of the key transcription factors in the regulation of multiple inflammatory genes including cytokines and chemokines.

In the case of T-ALL and MDS, an oncogenic role of JMJD3 has been well documented, which was largely attributed to its specific partnership with NF-κB and NOTCH15,21, two TFs whose overactivations are highly associated with the induction of multiple types of inflammatory cytokines and the proliferation of T cells3,40.