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ICs are also present in multiple inflammatory autoimmune disorders and are reported to propagate disease (Cross et al, 2001; Ho et al, 2010; Korganow et al, 1999; Kuhn et al, 2006; Monach et al, 2009; Munoz et al, 2010; Ruiz-Irastorza et al, 2010; Stuart & Dixon, 1983; Voulgarelis & Tzioufas, 2010; Zhao et al, 2008; Ziemssen & Ziemssen, 2005).
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"Anti-inflammatory" (5-ASA), "immuno-modulatory" agents (azathioprine its metabolite 6-MP and methotrexate) and the "immuno-suppressive" agent Tacrolimus® are used to treat IBD and multiple "inflammatory" and "autoimmune" diseases.
- Intracrine and paracrine actions of 1,25(OH)2D3 synthesized within immune cells may control inappropriate activation of interleukin-17-producing cells - —the Th17 aberrant response, which may play a major pathogenic role in multiple inflammatory and autoimmune disorders.
This review analyzes the known implications of leptin in multiple inflammatory conditions, including autoimmune diseases, and how this knowledge could be instrumental in the design of leptin-based manipulation strategies to help restoration of abnormal immune responses.
In addition, multiple reports in inflammatory autoimmune diseases and studies of human T-cell leukemia virus type-I (HTLV-1) associated lymphoma report elevated serum levels of sCD25 and defective suppression by Treg [31] [33].
Rheumatoid arthritis (RA) and multiple sclerosis (MS) are complex inflammatory autoimmune disorders in which genetic and environmental factors contribute to disease development [ 1].
Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS).
Multiple sclerosis (MS) is a complex inflammatory, autoimmune disease of the central nervous system (CNS).
Multiple sclerosis (MS) represents the prototypic inflammatory autoimmune disorder of the central nervous system and the most common cause of neurological disability in young adults, exhibiting considerable clinical, radiological and pathological heterogeneity.
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS).
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system.
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