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The proliferation of synovial fibroblasts in response to multiple inflammation factors is central to the pathogenesis of rheumatoid arthritis.
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To adequately analyze the various subtypes of COPD, studies that include multiple ethnic groups as well as multiple environmental factors that influence inflammation will be required in large sample sizes.
This is probably because inflammatory cytokines may be influenced by multiple factors during inflammation, whereas apoptosis-associated biomarkers are much simpler in their pathways and have less influence.
S. Typhimurium expresses multiple virulence factors capable of eliciting gut inflammation.
It is endemic in Asia (Forner et al., 2012; Tsukuma et al., 2005) and is linked to multiple etiological factors, including diet, alcohol, hepatotoxins, inflammation and microorganisms (El-Serag, 2011).
Multiple microbial factors promote development of TH2-inflammation, including the influence of certain microbial adjuvants during antigen presenting cell activation, and the nature of the protein itself.
In studying these associations, scholars should note that chronic inflammation itself may reflect the influence of multiple social factors.
The complex pathogenesis of Alzheimer's disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress.
The application of an autologue, platelet enriched suspension is supposed to cause multiple effects: The induction of a local inflammation process and the release and activation of multiple growth factors within complex signaling cascades.
Multiple independent pathways of evidence now pinpoint inflammation as a key regulatory process that links multiple risk factors for atherosclerosis and its complications with altered arterial biology [ 76].
The pathophysiology of SSc is complex and believed to be caused by multiple factors including vasculopathy, inflammation, and autoimmunity [ 4, 5].
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