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Cytokines have proven to be effective therapies in multiple indications including those in oncology, inflammation, and immunology.
HFNC has been tried for multiple indications, including secretion retention, hypoxemic respiratory failure, and cardiogenic pulmonary edema, to counterbalance auto-PEEP in patients with COPD and as prophylactic therapy or treatment of respiratory failure postsurgery and postextubation.
The PD-L1 IHC assay is currently being used in late-stage nivolumab clinical studies of multiple indications including NSCLC.
Both pan-TGF-β and TGF-β1, -β2 and -β3 isoform-specific antibodies are in development for multiple indications, including IPF.
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SVF has enormous potential for therapeutic application and is being investigated for multiple clinical indications including lipotransfer, diabetes-related complications, nerve regeneration, burn wounds and numerous others.
This toxin has multiple urological indications, including treatment of neurogenic and idiopathic detrusor overactivity.
BAR supervised the in vitro and in vivo use of CEP-33779 for multiple therapeutic indications, including RA, and edited the manuscript.
As noted above, IFN-β 1a is currently being used for a variety of clinical indications, including multiple sclerosis, and has shown dose-dependent efficacy in several clinical trials.
Misoprostol, a prostaglandin-E1 analogue, is employed for multiple obstetric and gynecologic indications, including treatment and prevention of postpartum hemorrhage, induction of abortion and induction of labor, among others (13– 13).
Widespread adoption of genomic technologies in the management of heterogeneous indications, including Multiple Myeloma, has been hindered by concern over variation between published gene expression signatures, difficulty in physician interpretation and the challenge of obtaining sufficient genetic material from limited patient specimens.
Moreover, there is emerging in vivo data to support the role of CB2R as a therapeutic target in other disease indications including osteoporosis, multiple sclerosis or in other diseases with an inflammatory component such as allergic contact dermatitis, colitis and atherosclerosis.
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