Sentence examples for multiple independent mutations from inspiring English sources

The development of an oncogenic state is a complex process involving the accumulation of multiple independent mutations that lead to deregulation of cell signalling pathways central to the control of cell growth and cell fate.

Multiple independent mutations have also been involved in the domestication and improvement of other crops; for example, Vrs1 for the six-rowed phenotype in barley [26] and Phr1 for grain discoloration in rice [2].

As was previously reported, we found that multiple independent mutations in sei lead to rapid seizures and paralysis in response to acute heat stress.

However, it is easy to see how multiple independent mutations, each in a different nutrient sensing system, may favor incremental improvements in the sensing of all nutrients through natural selection.

The actual development of cancer is a complex process, requiring the accumulation of multiple independent mutations each governing different pathways of cell growth and the cell cycle [ 21, 24].

It is interesting to note that many of the best-studied cases of genetic adaptation in humans have revealed multiple, independent mutations that confer an advantage to the same or similar selective pressures.

This presents an opportunity to systematically interrogate the whole human genome whether a selection signal shared across different populations is the consequence of a single mutation process followed subsequently by gene flow between populations or of convergent evolution due to the occurrence of multiple independent mutation events either at the same variant or within the same gene.

The accumulation of so many contributory mutations is hard to explain solely by the frequency of multiple independent mutation events.

Whether these mutations have arisen only once and are spreading throughout the species distribution or if multiple independent mutation events have occurred, remains to be understood.

Conserved long range haplotypes indicate that these deletions occurred once and have been inherited together with the surrounding genomic region, as opposed to arising via multiple independent mutation events.

In addition, the conserved long range haplotypes indicate that these deletions occurred once and have been inherited together with the surrounding genomic region, as opposed to arising via multiple independent mutation events.