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Co-localization of TDP-43 with SG markers is a robust observation that can be observed with multiple independent markers.
Importantly, multiple independent markers are required to reconcile gene evolution with species evolution.
To thoroughly explore population structure, multiple independent markers are required and intrapopulation variation needs to be evaluated [ 51].
The two processes are difficult to separate, but the patterns they generate can potentially be discriminated using multiple independent markers and geographical information [ 4].
The union test was more powerful than the kernel machine-based test for multiple independent markers with nonzero effects (Additional File 2 and Additional File 3).
Previous studies have shown that simultaneous analysis of multiple independent markers capable of predicting response to chemotherapy significantly improves the accuracy of the predictions (Salonga et al, 2000; Arango et al, 2001).
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Studies of multiple independent genetic markers, ideally using samples of known geographic provenance, would be needed to effectively address the question of the extent and consequences of gene flow among Hylobates species.
Testing selective sweep versus population bottleneck hypotheses requires an examination of multiple independent genetic markers [ 13].
Clinically, the combinatorial use of multiple independent tumor markers is effective for detecting lung cancer.
However these VNTR loci present multiple independent genetic markers and are therefore ideally suited for evolutionary analyses [ 10].
As a result, multiple independent phylogenetic markers with sufficient sequence divergence are necessary, and analytical approaches from population genetics may in some cases be more appropriate than traditional phylogenetic methods [ 5, 6].
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