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It cannot be explained by the presence of sex chromosomes without assuming multiple independent loci for sex determination in S. viminalis (Alström-Rapaport et al., 1997).
Unexpected allele frequencies can also arise from homoplasy, in which multiple independent loci yield identical fragment lengths.
Simulation studies have demonstrated that the error rates associated with such parameter estimations can be reduced by analyzing data from multiple independent loci [12], [13].
Correlated changes in genes are more prominent in genes with gene products of related function; these will affect rate estimation if these genes are treated as multiple "independent" loci.
Phylogenetic species were recognised as genealogically exclusive under GCPSR if they were concordantly supported by multiple independent loci.
Together, these results suggest that altitude may well be an important source of divergent selection within single rivers, and potentially acts on multiple independent loci.
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Assessing the relative importance of these selective and non selective factors would require additional sequence variation data from the same populations at multiple independent genetic loci since different migration patterns should affect every locus in the same way, whereas selection should affect the NAT2 locus specifically.
An alternative hypothesis is that there multiple, independent genetic loci within each QTL interval responsible for the observed phenotypes.
MIRU-VNTR typing analyzes the number of repetitive DNA sequences at multiple independent genetic loci.
Currently, different optimized multiplex assays are utilized to analyze multiple independent STR loci located on different chromosomes.
To the best of our knowledge, this is the first study that uses Next Generation Sequencing Technology to sequence multiple independent genetic loci from feces to infer species boundaries in endangered or critically endangered primates.
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