However, these studies have also revealed that such measures are unable to distinguish between ethnogenesis and multiple independent inventions of similar characteristics.
Here, we molecularly analyzed 28 additional patients, using multiple independent assays, and also report the phenotypic characteristics obtained from extensive multidisciplinary clinical study of a subset of these patients.
These findings have since then been confirmed by multiple independent studies, underscoring the prognostic value of these characteristics in CRC [ 8, 9].
Both early diagnosed CRCs and multiple independent CRC primaries have previously been suggested as characteristics associated with CRCs more likely to be due to an inherited predisposition.
In contrast, we investigate whether this regional fragility is an inherent genomic characteristic and is thus conserved over multiple independent lineages.
In this study, we comprehensively characterize the claudin-low subtype using an updated human tumor database and multiple independent data sets and present the pathological and chemotherapy response characteristics of this subtype of "triple negative" breast cancers.
Performance was assessed by internal cross-validation, multiple independent data sets, and comparison to existing algorithms using receiver-operating characteristic and Kaplan-Meier survival analysis.
We have chosen this model primarily because it explicitly incorporates the key characteristics of the Hill-Robertson effect – random sampling and selection at multiple (independent) loci.
In multiple, independent experiments, BT10-treated embryos display a consistent and penetrant phenotype (n>50), comprising a characteristic malformation of the ventral yolk structure and disruption of normal heart tube development (Fig. 4).
The defining characteristic of over fitting is the inability of the model to fit multiple independent datasets.
