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For discussions of the theoretical and statistical foundations of multiple imputation, see Nielsen (2003), Rubin (1987), and Zhang (2003).
Missing baseline data were replaced using multiple imputation (see online only supplementary methods).
For computations, we used the R-package "mice" which implements multiple imputation (see [ 13]).
We used the STATA ice command for multiple imputation (see reference by Royston et al (2007) of main paper).
Associations between biomarkers and 14-day mortality were estimated using Cox models with multiple imputation (see Supplementary Material).
The strength of the association between the CVD risk scores and frailty remained essentially the same after exclusion of incident CVD cases, and in multiple imputation (see supplementary web appendix, table S3).
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Missing baseline data were replaced using multiple imputations (see supplementary methods, available online only).
For further information on missing data and multiple imputations, see Sterne (2009) and Schafer and Graham (2002).
Variables considered in the imputation method (last model) were selected more than 5 times among the 10 replications of multiple imputations (see statistical method).
Use of the multiple imputation method (see above) was made to adjust 344 of these surveys.
All risk estimations from models employing only complete data were consistent with multiple imputation models (see Appendix, Supplementary data).
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