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The results from multiple imputation indicated that, despite selective response, the imputed prevalence estimates did not significantly differ from the crude prevalence estimates of health problems, indicating that the selective response did not result in highly biased prevalence estimates.
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The multiple imputations indicated a potential underestimation based on self reported data.
The c statistic was above 0.70 for the complete case and all multiple imputation models, indicating good sensitivity and specificity.
However, analyses from published technical data 4 and our sensitivity analysis using multiple imputation both indicate that bias resulting from missing data is negligible.
Results from the multiple imputation analysis, however, indicated consistency in findings in the reduced (complete case) and pooled (imputed) datasets.
Multiple imputation of missing stage indicated that the effect of age in older patients may have been slightly underestimated.
Diagnostic plots indicated that multiple imputation using MCMC converged well.
This limited simulation study indicates that multiple imputation with chained equations is an appropriate technique for dealing with missing information on tumour stage in population-based cancer registries, if the amount of unstaged cases is on a reasonable level.
First, we used multiple imputation to impute stage.
These missing covariates were imputed with a multiple imputation model.
As both hyper- and hypocortisolism indicate dysregulation, other approaches such as multiple imputation might not be suitable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com