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Trials must be designed to optimize the quality and applicability of the information generated, and there are multiple important methodological issues.
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In his lecture entitled 'Gene-environment interaction in the study of human complex diseases: what we can learn from rheumatoid arthritis and multiple sclerosis?' Lars Alfredsson (Karolinska Institutet, Stockholm, Sweden) raised several important methodological issues in relation to interactions.
Finally, the derivation of a weighted overall health knowledge score and its use in robust regression analysis is addressing an important methodological issue in assessing health knowledge on multiple topics.
First, some important methodological caveats.
The study also highlights important methodological issues.
An important methodological work, it is still in print.
The studies had important methodological limitations.
But there are equally important methodological questions outstanding.
As few methods for medium-scale targeted resequencing of numerous samples are available for non-model organisms, MIPs fill an important methodological gap.
There are also important methodological differences, one of which is the use of budgetary impact analysis.
However, it suffered from several important methodological limitations.
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