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In an attempt to localize SFRP1 or FRZB protein in the bleomycin model, we performed multiple immunohistochemistry optimization steps, but were unable to eliminate false positive background staining for both SFRPs.
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A multiple parameter optimization viz.
To balance these conflicts, we treated each training set as a separate objective in a multiple objective optimization calculation.
In blue, we show the observed distribution of scores after multiple optimization runs.
Some of the parameters showed almost no variance among the results of multiple optimization runs.
Combinations of multiple optimization objectives can be expressed in ADP by products of algebras.
Therefore multiple runs of optimization methods are required to achieve a relatively consistent result.
The acceptable parameter values for this model, found by multiple optimization runs, varied over several orders of magnitude.
This is a multiple-variable and multiple-constraint optimization problem.
Multiple-query optimization.
There are two general approaches to multiple-objective optimization.
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