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These data imply that GCase deficiency and resultant substrate accumulation stimulated multiple immune response genes.
Multiple immune response pathways including specific molecular targets of abatacept were significantly downregulated in improvers post-treatment but were unchanged in non-improver and placebo groups.
When multiple immune response measurements were reported reflecting seroprotection at different intervals during the primary vaccine series, the result after the final dose was recorded.
We identified 25 pathways that were highly significantly decreased in improvers post-treatment (FDR <1%%), including multiple immune response pathways such as interleukin and interferon signaling (Fig. 4d).
Multiple immune response (e.g., chemokine and cytokine signaling) pathways went down and cell cycle functional terms went up in improvers post-treatment (Fig. 2c).
In some instances, genes expressed differentially in SAID were found to play a regulatory role in multiple immune response and inflammatory pathways.
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It is unlikely that a single antigen would give the required protective results due to the complex structure of the different stages in the schistosomal life cycle besides the multiple immune responses involved.
In vitro and in vivo studies revealed pleiotropic activities of IL-10 on B and T cells and taken together, that a critical function of IL-10 is to suppress multiple immune responses through individual actions on T cells, B cells, antigen presenting cells and other cell types and to skew the immune response from Th1 to Th2 [ 34].
Here we describe the effects of arsenic on the expression levels of a cohort of genes predicted to affect multiple vertebrate immune response processes.
Genetic and antigenic heterogeneity of LB Borrelia spirochetes presumably is determined by balancing selection under the pressure of their multiple reservoirs' immune responses [30].
C5a, an anaphylatoxin, induces or amplifies multiple innate immune responses.
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