Because an optimal antitumor response requires coordination of multiple immune, tumor, and microenvironment effector cells, novel approaches targeting distinct mechanisms of action likely in combination are needed.
Tumors may induce immune tolerance or resist destruction by activated immune effector cells through multiple proposed mechanisms [ 21].
That such a system exists is evidenced by recent experiments that identify QS-dependent alterations of multiple genetic programs, epithelial cells, and immune effector cells in patients [ 6].
In summary, IL-12 possesses multiple biological properties that are capable of governing immune effector actions against a variety of malignancies and, despite some setbacks, remains the center of interest as a recognized anticancer immunotherapeutic agent.
Together, these results argue that Btk inhibition suppresses inflammation, bone erosion, and autoimmunity in vivo by affecting the function of multiple immune cells involved in both the propagation and effector phases of CIA.
Phagocytosis of immunocytes is a highly integrated immune process, accomplished by multiple genes involved in pathogen recognition, signal transducing and immune effector expression [ 25, 48, 49].
Nematode-derived protease inhibitors are believed to have multiple, specific abilities for the host immunomodulation, playing on various immune effector mechanisms.
They are also believed to have multiple, specific abilities for the host immunomodulation, playing on various immune effector mechanisms (Hartmann & Lucius, 2003).
Several immune-related GO terms including immunoglobulin domain, immune effector process and leukocyte mediated immunity were significantly enriched (Table 3).
