A member of the type 2C phosphatases (PP2Cδ), Wip1 has been shown to be amplified and overexpressed in multiple human cancer types, including breast and ovarian carcinomas.
HIV is capable of infecting multiple human cell types, but for simplicity's sake, we will focus on HIV infection of CD4-positive immune cells, a.k.a.a
Defects in genes required for DNA replication and repair always cause genetic instability and are associated with multiple human cancer types (Preston et al., 2010).
Gene targeting with adeno-associated virus (AAV) vectors has been demonstrated in multiple human cell types with maximal targeting frequencies without engineered nucleases.
Excess iron is tightly associated with tumorigenesis in multiple human cancer types through a variety of mechanisms including catalyzing the formation of mutagenic hydroxyl radicals, regulating DNA replication, repair and cell cycle progression, affecting signal transduction in cancer cells, and acting as an essential nutrient for proliferating tumor cells.
The recently developed gene editing approach called clustered regularly interspaced short palindrome repeats-associated nuclease (CRISPR -Cas9, CRISPR -Cas9y knocanout most regions of the genome at the DNA level with fewer OTEs than RNAi, in multiprecisely cell types, thus overcoming the limitations of the other approaches.
PTK6 is expressed in multiple human tumor types, including breast and ovarian tumors [14] [16], [18].
The search results revealed that EZH2 is consistently upregulated in multiple human cancer types including breast cancer, while CDKN1C is downregulated in these tumors (Figure 6A).
Current studies revealed that the dysregulation of miR-125 occurs in multiple human cancer types [ 9– 13].
These results suggest that the ZC3HAV1L-CHMP1A chimeRNA RNA is common across multiple human tissue types, both healthy and diseased.
