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These intervention results were in consistent with the positive correlation between NAT expression and distal pA site usage in multiple human tissues and cell lines (Figs. S1 and S5).
Our exploration of the probe-level exon array data indicates the existence of a subset of exon array probes with highly correlated signals in multiple human tissues.
We have shown that the expression of clusters of genes varies in a development-dependent manner in multiple human tissues.
Notably, most mismatches showed low ratios (< 20%) from multiple human tissues, while some showed high mismatch ratios (>60%).
Horvath reported that biological age could be predicted by DNAm of 353 CpG sites in multiple human tissues [ 11].
Our findings are consistent with more recent studies showing significant positive correlations between DNA hypermethylation and low gene activity at CpG-poor promoters in multiple human tissues [ 24].
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Human northern blot analysis: A multiple human tissue blot was purchased from Clonetech (BD Bioscience) and hybridized with labeled probes following the manufacturer's recommendation.
Some examples of the expression of UGT1A isoforms among multiple human tissue samples are provided in Figure 1.
Northern blot was performed with a commercial 12-lane multiple human tissue blot (Clontech) using full length human MULAN cDNA to generate the probe.
Expression of the human ZNF131 gene was measured in multiple cell lines and multiple human tissue cDNA libraries.
PSS was set up to further reduce unknown genomic noise by taking advantage of multiple human tissue RNA-seq datasets.
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