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Cryptocandin (from endophytic fungus Cryptosporiopsis quercina) [40] is an antimycotic drug against multiple human pathogens including C. albicans and Histoplasma capsulatum (causal agent of the lung disease Histoplasmosis), in addition to T. rubrum and T. mentagrophytes [41].
Moreover, species that serve as vectors of multiple human pathogens were all favored by deforestation, including Anopheles bancroftii, Anopheles darlingi, Anopheles farauti, Anopheles funestus s.l., Anopheles gambiae s.l., Anopheles subpictus, Aedes aegypti, Aedes vigilax, Culex annulirostris, and Culex quinquefasciatus.
The repeats-in-toxin (RTX) family of exoproteins is associated with the virulence of multiple human pathogens, including Escherichia coli, Bordetella pertussis, Serratia marcescens, and Pseudomonas aeruginosa.
The hCMEC/D3 cell line has been widely used to model brain endothelium for investigating the molecular mechanisms of its interaction with and response to multiple human pathogens (viruses, fungi, bacteria and parasites) known to affect the CNS.
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In the former case, the SAM-I riboswitch is an attractive target because this structured RNA element is found only in bacterial mRNAs and regulates multiple genes in several human pathogens.
Antimicrobials are an essential component of clinical medicine that are threatened by increasing resistance to multiple drugs in major human pathogens.
They were first detected on plasmids bearing single and multiple drug resistance determinants in human pathogens, and it is abundantly clear that integrons have played a major role in the evolution of this public health menace.
Here we focus on the characterization of odorant-binding proteins (OBPs), "plus-C" odorant-binding proteins ("plus-C" OBPs), chemosensory proteins (CSPs) and sensory neuron membrane proteins (SNMPs) families from the Southern house mosquito, Culex quinquefasciatus, a vector of pathogens implicated in multiple human diseases.
The pTZ2162 plasmid also shares near sequence identity to multiple genes in Staphylococcus haemolyticus and Staphylococcus epidermidis human pathogens (data not shown).
In a list of 1,415 human pathogens, 61% are known to be zoonotic, and multiple host pathogens are twice as likely to be associated with an emerging infectious disease of humans (26).
Predictably, DsbA disruption affects multiple downstream effector molecules, resulting in pleiotropic effects on the virulence of important human pathogens.
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CEO of Professional Science Editing for Scientists @ prosciediting.com