It is striking that, in multiple human lung cancer cell lines of adenocarcinoma and squamous lineage, inducible expression of SOX2 consistently promoted nuclear pStat3 accumulation.
Similarly, ectopic expression of miR-137 in A549, NCI-H460, and NCI-H520 resulted in G1 cell cycle arrest [ 65]. miR-129 induced G1 phase arrest in multiple human lung adenocarcinoma cell lines, suggesting miR-129 targeting of G1/S phase-specific regulators [ 54].
We recently demonstrated that HSF1 is highly expressed in multiple human tumors including lung, colon, breast, and ovarian cancers.
b) Human lung tumors: The human multiple lung cancer tissue arrays with unmatched normal adjacent tissues (US Biomax Inc LC2422 (10 cases) and LC1005 (77 cases) were used to determine the expression of GPER patterns.
Accumulating data show that GA has a broad spectrum of antitumor activity against diverse tumor cells, such as human multiple myeloma U266 cells, human lung carcinoma SPC-A1 cells, and human hepatoma SMMC-7721 cells [21,22]. SMMC-7721 cells [21,22]
AGR2 has been implicated in cancer pathogenesis and has been found to be up-regulated in multiple human cancers, including breast, lung, and prostate [ 13, 14, 18- 20, 30].
A study using multiple cell cocultures of human lung epithelial cells, macrophages, mast cells, and endothelial cells demonstrated that when cocultures were exposed, a stronger cytokine production was observed in comparison to the responses obtained on single culture [ 203].
Zheng at al. measured the expression of multiple UGTs in 32 human lung tissues by duplex RT-PCR and found that UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 were not expressed.
Consistent with its role in early developmental stages, the IGF2BP1 gene is downregulated in differentiated cell types, and overexpression of IGF2BP1 is known to occur in multiple human cancers, including breast, lung and colon [ 49- 52].
The highly pathogenic influenza virus H5N1 has been shown to infect multiple human organs other than the lungs, suggesting that H5N1 can replicate in these organs.
In addition to the work done in cell culture, increasing numbers of studies have shown that TAZ are elevated or activated in multiple human cancers, including breast cancer, glioblastoma, lung cancer, colorectal cancer, and oral squamous cell carcinoma (See discussion below).
