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The gut microbiota regulate susceptibility to multiple human diseases.
The RET receptor tyrosine kinase is essential to vertebrate development and implicated in multiple human diseases.
The heparin-binding glycoprotein YKL-40 (CHisL1) intimatelyely associated with microvascularization in multiple human diseases including cancer and inflammation.
Recently, accumulative evidences have revealed the PXR- and CAR-mediated herbal effect against multiple human diseases, including inflammatory bowel disease (IBD), cholestatic liver disease, and jaundice.
The identification of novel compounds able to modulate IL-22/IL-22R IL-22/IL-22R IL-22/IL-22Rute to new therapeuticomplexegies in multiple human diseases.
Our goals are to enhance understanding, diagnosis, treatment, and prevention of multiple human diseases, to cultivate a range of interdisciplinary basic and translational stem cell research and encourages rapid translation of discoveries into innovative and practical clinical applications.
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The GAIN domain is evolutionarily conserved from tetrahymena to mammals, is the only extracellular domain shared by all human cell-adhesion GPCRs and PKD proteins, and is the locus of multiple human disease mutations.
Population studies of polymorphisms in genes encoding TLRs or their downstream signalling molecules in conjunction with limited extrapolation from animal studies have directly linked these pathways to multiple human disease processes.
Defects in Ca2+ homoeostasis play a role in multiple human disease pathologies [ 38– 41] and, although the mammalian Ca2+-signalling apparatus itself appears to exhibit resilience to damage of single components (most probably through functional redundancy), defects in this machinery can also lead directly to disease [ 42].
Neutrophils play a pivotal role in the pathophysiology of multiple human inflammatory diseases.
Spread of amyloid seeding by ISF may also occur in multiple human brain diseases involving CAA.
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