Burns, M.B., Temiz, N.A. & Harris, R.S. Evidence for APOBEC3B mutagenesis in multiple human cancers.
Morris, L.G. et al. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.
Ginkgo biloba extract (GBE) has exhibited antitumor activity in multiple human cancers.
Mutations within the ING1 gene and altered expression levels of ING1 are found in multiple human cancers.
Our results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
Activation of inflammatory pathways in endothelial cells contributes to tumour growth and progression in multiple human cancers.
Notably, we find that transcriptional or genomic aberrations of BRAFP1 occur frequently in multiple human cancers, including B cell lymphomas.
Besides its role in normal tissue development, TAZ plays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), and stemness in multiple human cancers.
Consistent with the observation that TAZ is highly expressed in multiple human cancers, TAZ displays the transforming properties in cell culture system.
In addition to the work done in cell culture, increasing numbers of studies have shown that TAZ are elevated or activated in multiple human cancers, including breast cancer, glioblastoma, lung cancer, colorectal cancer, and oral squamous cell carcinoma (See discussion below).
Consistently, the expression of TAZ is elevated in multiple human cancers, such as invasive ductal breast cancer and glioblastoma (Bhat et al., 2011; Chan et al., 2008; Cordenonsi et al., 2011; Zhou et al., 2015a), implying the oncogenic roles of TAZ in human cancer development.
