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Treatment with INH1 suppresses the proliferation of multiple human breast cancer cells in vitro.
In a previous proteomic analysis of purified membrane preparations from multiple human breast tumour-derived cell lines (Adam et al, in press) we identified a unique protein BCMP11.
The HEY family of genes has been proposed to function as surrogate markers of Notch activity in multiple human breast cancer cell lines [ 45, 46].
As such, multiple human breast tumor cell lines exhibit down-regulation of connexin gene expression [ 230], and deficiency of Cx43 gap junctions is considered as a marker of breast tumors [ 231].
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Also recent are Martin Puryear's African-looking hut made of wood, wire mesh and tar and Louise Bourgeois's bizarre bronze of a headless, hermaphroditic hound with multiple human breasts.
To further examine the expression pattern of this gene in breast cancer cell lines and normal tissues, we performed Northern blot analyses with mRNAs from multiple human tissues and breast cancer cell lines using a cDNA fragment corresponding to the 3' untranslated region of the MELK gene as a probe.
The current study provides a novel link between overexpression of collinear Hox genes and multiple microRNAs in human breast malignancy.
In addition to the work done in cell culture, increasing numbers of studies have shown that TAZ are elevated or activated in multiple human cancers, including breast cancer, glioblastoma, lung cancer, colorectal cancer, and oral squamous cell carcinoma (See discussion below).
Additionally, various studies have reported significant loss of WWOX expression in multiple human neoplasias including breast, prostate, ovarian, lung and liver cancer [6], [7].
This tightly regulated 5-HT system is subverted in multiple ways in human breast cancers.
The expression of the proto-oncogene c- myc is frequently deregulated, via multiple mechanisms, in human breast cancers.
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