Sentence examples for multiple host proteins from inspiring English sources

Indeed, these and other toxins, which neutralize or alter the activities of multiple host proteins, can be used to perform a variety of in vivo pharmacological studies to complement classical genetic loss-of-function studies.

Such a structural plasticity appears to be due to intrinsic disorder of the EPIYA-containing region, which enables the bacterial effectors to undergo efficient phosphorylation and mediate promiscuous interaction with multiple host proteins.

Together, these findings revealed a strong mechanistic connection underlying simultaneous recognition of multiple host proteins by EspG, and suggested that the scaffolding properties of a bacterial effector protein may allow selective control over signaling pathways at the Golgi apparatus.

The M protein is a vaccine antigen and major virulence factor of GAS, which affects adherence and invasion to host cells via interaction with multiple host proteins including fibrinogen (Smeesters, McMillan and Sriprakash 2010; Ghosh 2011; Anderson et al., 2014), and inhibits phagocytosis of GAS to overcome innate immunity (Smeesters, McMillan and Sriprakash 2010).

Based on pharmacological inhibitor experiments, it was also reported that multiple host protein kinases, such as phosphatidylinositol 3-kinase (PI3-K), epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR) and heterotrimeric G proteins may also play a role in epithelial cell invasion by C. jejuni [ 11, 21, 30].

Many viruses initiate infection through a multistep process involving multiple host cell receptor proteins (for review, see Grove and Marsh, 2011).

Hence, taking all our current observations in view, it appears that different proteins encoded by IAV, such as NP and M1, utilize multiple mechanisms to target strategic host proteins involved in regulation of the cellular apoptotic network for instance Hsp70, clusterin, Bax, and now API5.

The CagA protein is involved in many of these processes through multiple interactions with a number of host proteins.

Upon translocation, CagA localizes to the internal surface of the plasma membrane, where it is phosphorylated on C-terminal variable region tyrosine residues by multiple host Src tyrosine kinase family member proteins [ 20- 22].

Adenovirus cell entry requires interactions of multiple host cell receptors with distinct virus capsid proteins.

It is possible that a bacterial protein showing no similarity to host proteins might be involved in multiple metabolic pathways, but its disruption might be of no therapeutic benefit.