Sentence examples for multiple hit model from inspiring English sources

The multiple hit model explains how antibodies neutralize viruses, and recent data on the stoichiometry of antibody neutralization suggest that the organization of viral surface proteins on viruses, in addition to virus size, influences the level of antibody occupancy required for neutralization.

Overall, we interpret these findings in light of the "multiple hit" model of diabetes.

Whether the disease progresses from an initial injury to ARDS or continues to progress from mild-moderate ARDS to severe ARDS probably depends on a chain reaction based on these multiple hits (Figure 1). Figure 1 Multiple-hit model.

Our results could be explained by a multiple-hit model.

Current knowledge is in line with a multiple-hit model in which IBD triggering is due to neither host susceptibility nor the environment nor the microbiota but due to the concomitant occurrence of intestinal barrier dysfunction that allows abnormal antigenic stimulation of immunity in a susceptible host prone to mount uncontrolled inflammatory responses.

One possibility, however, is that MB established a "mutant steady state" (Clarke et al. 2000) in which the homeostatic state of those cells is abnormal and confers an increased rate of cell death in response to a subsequent challenge, a variant of the multiple-hit model posed in support of these experiments.

Hidekazu Tsukamoto (University of Southern California School of Medicine, Los Angeles, CA, USA) discussed second and multiple-hit models of ALD.

Incomplete disease penetrance in FIP supports this 'multiple hit' model, and it is likely that as-yet-unidentified secondary genetic factors and/or specific environmental exposures are needed to develop clinically significant lung disease.

Although many monogenic and chromosomal causes of ID are known, a "multiple hit"/oligogenic model is emerging, where combinations of variants are necessary to disrupt normal neuronal development and underlie a range of disorders from idiopathic epilepsy to autism and ID (Coe et al, 2012).

A multiple parallel hit model has been proposed for the pathogenesis of NASH where the initial step (first-hit) involves fat accumulation in liver and many hits, especially gut-derived and adipose tissue-derived factors, may act in parallel, resulting in hepatic inflammation [10,11].

Different substitution models yielded very similar results and GTR model with multiple hit corrections was eventually used in this study.