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This resource can be used to analyze and compare binding modes across multiple histone recognition modules, to evaluate the chemical tractability of binding sites involved in epigenetic signaling and design small molecule inhibitors.
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Filippakopoulos, P. et al. Histone recognition and large-scale structural analysis of the human bromodomain family.
Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300.
Cells regulate transcription by coordinating the activities of multiple histone modifying complexes.
Zhou et al. Genome-wide profiling of histone H3 lysine 9 acetylation and dimethylation in Arabidopsis reveals correlation between multiple histone marks and gene expression.
Zhou, J. L. et al. Genome-wide profiling of histone H3 lysine 9 acetylation and dimethylation in Arabidopsis reveals correlation between multiple histone marks and gene expression.
We concurrently map relative levels of multiple histone modifications across multiple samples, each comprising as few as a thousand cells.
Nady N, Krichevsky L, Zhong N, Duan S, Tempel W, Amaya MF, Ravichandran M, Arrowsmith CH, "Histone Recognition by Human Malignant Brain Tumor Domains," J. Molecular Biology 423 (5), 702-718 (2012).
The molecular mechanism of the histone recognition is elucidated based on a 2.1 A-resolution crystal structure of the PHD-H3K4me3 complex.
Dear Editor, Histone recognition by reader modules constitutes a major mechanism for epigenetic regulation (Jenuwein and Allis 2001).
To further confirm the role of TLR9 in histone recognition, we used the TLR9 antagonist ODN2088.
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