Sentence examples for multiple histone modifying from inspiring English sources

Cells regulate transcription by coordinating the activities of multiple histone modifying complexes.

Biochemical studies of human HCF-1 have shown that HCF-1 associates with multiple histone modifying activities, including the mixed-lineage leukemia (MLL) family of histone H3 lysine 4 (H3K4) methyltransferases, MOF1 histone acetyltransferase (HAT), and Sin3 histone deacetylase (HDAC) [9] [12], suggesting a broad role in chromatin modification.

Possibly, combined inhibition of multiple histone-modifying enzymes, such as LSD1, HDAC2 and SIRT1, could lead to improved treatment of breast cancer patients.

Therefore, histones are modified locally and globally through multiple histone-modifying enzymes with different substrate specificities, generating hierarchical patterns of modifications from single promoters to large regions of chromosomes and even single cells.

Furthermore, expression and functional studies suggest that various histone modifying epigenetic enzymes likely participate in multiple steps during the formation of adult intestinal stem cells during metamorphosis.

The Kcnq1ot1 lncRNA has been shown to silence multiple genes in placental cells by the action of repressive POLYCOMB histone modifying enzymes [ 87, 88].

These methyl-CpG-binding proteins can exert regulation over the expression of multiple genes via their interaction with methylated DNA and their association with histone modifying enzymes [ 17].

Zhang, K. & Dent, S. Y. Histone modifying enzymes and cancer: going beyond histones.

PRC1 and PRC2 have histone modifying activities, catalyzing mono-ubiquitination of histone H2A (H2and19u1) and trimethylation of H3 lysine 27 (H3K27me3), respectively.

For example, DNMT1 directly interacts with histone modifying enzymes such as histone H3K9 methyltransferase SUV39H1, histone H3K27 methyltransferase EZH2, and histone deacytelase HDAC1 and HDAC2 [ 14, 21].

Rest recruits multiple cofactors, histone modifying and chromatin remodelling activities, all of which underwrite the complexity of Rest activity [14] [16].